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A study demonstrated that -asarone and levodopa elevated dopamine levels in 6-hydroxydopamine-induced Parkinson's disease rats, enhancing therapeutic efficacy by modulating P-gp and TJs proteins at the BBB [145]

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This model is still primarily theoreticalbut many clinicians working at the intersection of gut health, endocrinology, and womens health use some version of it in practice

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Grndemann suggested naming OCTN1 the ergothioneine transporter (ETT) to reflect its predominant biological role

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Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

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J Neurochem 84 : 11731183

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